- County Human Population: 2,503
Columbia County is a county located in the north central portion of the U.S. state of Florida. As of the 2010 census, the population was 67,531. Its county seat is Lake City.
Columbia County is a county located in the north central portion of the U.S. state of Florida. As of the 2010 census, the population was 67,531. Its county seat is Lake City.